Understanding and targeting the pathophysiology of youth-onset type 2 diabetes

The goal of this project is to work in collaboration with a national consortium of 15 Centers to establish and follow a cohort of children at risk of developing type 2 diabetes to identify causative and predictive factors

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Funding 

Funded by UO1 DK 134984 with total funding of $4m over 6 years from February 2023 to February 2029.

More details on this funding at NIH reporter:
Understanding and Targeting the Pathophysiology of Youth-onset Type2 Diabetes → 

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Key Publications

Associations of Dietary Sugars with Liver Stiffness in Latino Adolescents with Obesity Differ Based on PNPLA Genotype and Liver Disease Severity

Rapid Decline in Beta-Cell Function and Increasing Adiposity is Associated with Conversion to Type 2 Diabetes in at Risk Latino Youth

Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Control Trial 

PNPLA3 Genotype, Arachidonic Acid Intake and Unsaturated Fat Intake Acid Intake Influences Liver Fibrosis in Hispanic Youth with Obesity

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